ArticlesReviewsBook Chapters – Patents

Articles in Peer Reviewed Journals

(Check UoB Repository or ChemRxiv for OA options of the manuscripts)

42. Adoni, P.; Romanyuk, A.; Overton, T. W.; Fernandez-Trillo, P. Polymer-Induced Biofilms for Enhanced Biocatalysis. Mater Horizons 2022. doi:10.1039/d2mh00607c. (ChemRxiv)

41. Li, H.; Han, L.; Li, Q.; Lai, H.; Fernández-Trillo, P.; Tian, L.; He, F. Hierarchical Chiral Supramolecular Nanoarchitectonics with Molecular Detection: Helical Structure Controls upon Self-Assembly and Coassembly. Macromol Rapid Comm 2021, 2100690. doi:10.1002/marc.202100690.

40. Li, H.; Han, L.; Zhu, Y.; Fernández-Trillo, P.; He, F. Transformation from Rod-Like to Diamond-Like Micelles by Thermally Induced Nucleation Self-AssemblyMacromolecules 54, 5278–5285 (2020) doi:10.1021/acs.macromol.1c00744.

39. Wilkinson, A. A. et al. Site-Selective and Rewritable Labeling of DNA through Enzymatic, Reversible, and Click ChemistriesACS Central Sci (2020) doi:10.1021/acscentsci.9b01023.

38.O, J. M. do et al. Poly(triazolyl methacrylate) glycopolymers as potential targeted unimolecular nanocarriersNanoscale, 11, 21155–21166 (2019).

Graphical abstract: Poly(triazolyl methacrylate) glycopolymers as potential targeted unimolecular nanocarriers

37. Oliver Creese, Pavan Adoni, Guanlong Su, Andrey Romanyuk and Paco Fernandez-Trillo. Poly(Boc-acryloyl hydrazide): The importance of temperature and RAFT agent degradation on its preparationPolym. Chem. (2019) doi: 10.1039/C9PY01222B (ChemRxiv)


36. Adam Kolodziej, Cécile S. Le Duff,Julian Bergueiro, Marc Walker, Alexander Keeler, Andrea E. Russell, Paco Fernandez-Trillo, and Paramaconi Rodriguez. Design of Surface-Modified Electrodes for the Electrochemical Adsorption of Platinum-Based Anticancer Drugs. Chem Mater (2019) doi: 10.1021/acs.chemmater.9b02382F (UoB Repository)


35. Marisa Juanes, Oliver Creese, Paco Fernandez-Trillo and Javier Montenegro. Messenger RNA delivery by hydrazone-activated polymers. Med Chem Comm (2019) 10, 1138-1144. (UoB Repository)


34. Nicolas Perez-Soto, Oliver Creese, Francisco Fernández-Trillo, and Anne-Marie Krachler. Aggregation of Vibrio cholerae by cationic polymers enhances quorum sensing but over-rides biofilm dissipation in response to autoinduction. ACS Chemical Biology (2018) 13, 3021-3029. (biorXiv) (UoB Repository)

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33. Juan M Priegue, Irene Lostalé-Seijo, Daniel Crisan, Juan R. Granja, Francisco Fernández-Trillo, and Javier Montenegro. Different Length Hydrazone Activated Polymers for Plasmid DNA Condensation and Cellular Transfection. Biomacromolecules19 (7), 2638–2649 (2018). (UoB Repository)


32. Insua, I., Petit, M., Blackman, L., Keogh, R., Pitto-Barry, A., O’Reilly, R., Peacock, A., Krachler, A.-M. & Fernandez-Trillo, F. Structural determinants of the stability of enzyme‐responsive polyion complex (PIC) nanoparticles targeting Pseudomonas aeruginosa’s elastase. ChemNanoMat. 8, 807-814. doi: 10.1002/cnma.201800054 (2018). (UoB Repository)


31. O’Donoghue, E. et al. Lipopolysaccharide structure impacts the entry kinetics of bacterial outer membrane vesicles into host cells. Plos Pathog 13, e1006760 (2017). (UoB Repository)


30. Kolodziej, A., Figueiredo, M., Koper, M., Fernandez-Trillo, F. & Rodriguez, P. Phosphate-mediated electrochemical adsorption of cisplatin on gold electrodesElectrochimica Acta 248, 409–415 (2017). (UoB Repository)


29. Blanco-Fernandez, B., Concheiro, A., Makwana, H., Fernandez-Trillo, F., Alexander, C. & Alvarez-Lorenzo, C. (2017). Dually sensitive dextran-based micelles for methotrexate delivery. RSC Advances 7(24), 14448–14460. (UoB Repository)


28. I. Insua, L. Zizmare, A. F. A. F. Peacock, A. M. Krachler, and F. Fernandez-Trillo, Polymyxin B containing polyion complex (PIC) nanoparticles: Improving the antimicrobial activity by tailoring the degree of polymerisation of the inert component. Sci Rep, 2017, 7, 9396I. (UoB Repository)


27. Kolodziej, A., Fernandez-Trillo, F. & Rodriguez, P. Determining the parameters governing the electrochemical stability of thiols and disulfides self-assembled monolayer on gold electrodes in physiological medium. J Electroanal Chem (2017). doi:10.1016/j.jelechem.2017.07.039 (UoB Repository)


26. D. Crisan, O. Creese, R. Ball, J. L. Brioso, Ben Martyn, J. Montenegro and F. Fernandez-Trillo, Poly(acryloyl hydrazide), a versatile scaffold for the preparation of functional polymers: synthesis and post-polymerisation modification. Polym. Chem., 2017, 31, p. 4576-4584. (UoB Repository)


25. E. P. Magennis, N. Francini, F. Mastrotto, R. Catania, M. Redhead, F. Fernandez-Trillo, D. Bradshaw, D. Churchley, K. Winzer, C. Alexander and G. Mantovani, Polymers for binding of the gram-positive oral pathogen Streptococcus mutans. PLoS ONE, 2017, 12, e0180087. (UoB Repository)


24. N. Perez-Soto, L. Moule, D. Crisan, I. Insua, L. Taylor-Smith, K. Voelz, A. M. Krachler and F. Fernandez-Trillo, Engineering microbial physiology with synthetic polymers: cationic polymers induce biofilm formation in Vibrio cholerae and downregulate the expression of virulence genes. Chem Sci. 8, 5291-5298. (2017), doi: 10.1039/C7SC00615B. (biorXiv) (UoB Repository)


23. I. Insua, S. Majok, A. F. A. Peacock, A. M. Krachler, F. Fernandez-Trillo, Preparation and antimicrobial evaluation of polyion complex (PIC) nanoparticles loaded with polymyxin B, Eur. Polym. J. (2017), 87, 478-486. – (UoB Repository)


22. E. Leire et al., Dendrimer mediated clustering of bacteria: improved aggregation and evaluation of bacterial response and viability. Biomater. Sci. (2016), 4, 998-1006. – (UoB repository)


21. J. M. Priegue et al., In Situ Functionalized Polymers for siRNA Delivery. Angew. Chem., Int. Ed. (2016), 55, 7492–7495. – (UoB repository)


20. I. Insua et al., Enzyme-responsive polyion complex (PIC) nanoparticles for the targeted delivery of antimicrobial polymers. Polym. Chem. 7, 2684–2690 (2016). – (UoB repository)

For Web

19. Louzao, I., Sui, C., Winzer, K., Fernandez-Trillo, F., and Alexander, C. (2015) Cationic polymer mediated bacterial clustering: Cell-adhesive properties of homo- and copolymers. Eur. J. Pharm. Biopharm. 95, 47-92 (2015). – (UoB repository)


18. E Peter Magennis, Francisco Fernandez-Trillo, Cheng Sui, Sebastian G Spain, David J Bradshaw, David Churchley, Giuseppe Mantovani, Klaus Winzer, and Cameron Alexander. Bacteria-instructed synthesis of polymers for self-selective microbial binding and labelling. Nat. Mater. 13, 748–755 (2014). – (UoB repository)

Figure 1_AS

17. Magnusson, J. P., Fernandez-Trillo, F., Sicilia, G., Spain, S. G. & Alexander, C. Programmed assembly of polymer-DNA conjugate nanoparticles with optical readout and sequence-specific activation of biorecognition. Nanoscale 6, 2368–2374 (2014). (UoB repository)


16. Leong T Lui, Xuan Xue, Cheng Sui, Alan Brown, David I Pritchard, Nigel Halliday, Klaus Winzer, Steven M Howdle, Francisco Fernandez-Trillo, Natalio Krasnogor, and Cameron Alexander. Bacteria clustering by polymers induces the expression of quorum-sensing-controlled phenotypes. Nat. Chem. 5, 1058–1065 (2013). – (UoB repository)


15. Sicilia, G., Grainger-Boultby, C., Francini, N., Magnusson, J. P., Saeed, A. O., Fernandez-Trillo, F., Spain, S. G., and Alexander, C. Programmable polymer-DNA hydrogels with dual input and multiscale responses. Biomater. Sci. 2, 203 (2013). – (UoB repository)


14.- Fowler, R., Vllasaliu, D., Fernández-Trillo, F., Garnett, M., Alexander, C., Horsley, H., Smith, B., Whitcombe, I., Eaton, M. and Stolnik, S. Nanoparticle Transport in Epithelial Cells: Pathway Switching Through Bioconjugation. Small 9, 3282–3294 (2013). 

Figure 1

13.- Cooper, G. J. T., Bowman, R. W, Magennis, E. P., Fernández-Trillo, F., Alexander, C., Padgett, M. J., and Cronin, L. Directed Assembly of Inorganic Polyoxometalate-based Micrometer-Scale Tubular Architectures by Using Optical Control. Angew. Chem., Int. Ed. 51, 12754–12758 (2012).


12.- Yaşayan, G., Redhead, M., Magnusson, J. P., Spain, S. G., Allen, S., Davies, M. C., Alexander, C., and Fernández-Trillo, F. Well-defined polymeric vesicles with high stability and modulation of cell uptake by a simple coating protocol. Polym. Chem. 3, 2596–2604 (2012).


11.- Xue, X., Pasparakis, G., Halliday, N., Winzer, K., Howdle, S. M., Cramphorn, C. J., Cameron, N. R., Gardner, P. M., Davis, B. G., Fernández-Trillo, F., and Alexander, C. Synthetic Polymers for Simultaneous Bacterial Sequestration and Quorum Sense Interference. Angew. Chem., Int. Ed. 50, 9852–9856 (2011).


10.- Fernández-Trillo, F., Pacheco-Torres. J., Correa, J., Ballesteros, P., López-Larrubia, P., Cerdán, S., Riguera, R., and Fernández-Megía, E. Dendritic MRI Contrast Agents: An Efficient Prelabeling Approach Based on CuAAC. Biomacromolecules 12, 2902–2907 (2011).

9.- Yaşayan, G., Saeed, A. O., Fernández-Trillo, F., Allen, S., Davies, Martyn C., Jangher, A., Paul, A., Thurecht, K. J., King, S. M., Schweins, R., Griffiths, R., Magnusson, J. P., and Alexander, C. Responsive hybrid block co-polymer conjugates of proteins–controlled architecture to modulate substrate specificity and solution behaviour. Polym. Chem. 2, 1567–1578 (2011).


8.- Smaldon, J., Romero-Campero, F. J., Fernández-Trillo, F., Gheorghe, M., Alexander, C., and Krasnogor, N. A computational study of liposome logic: towards cellular computing from the bottom up. Syst. Synth. Biol. 4, 157–179 (2010).


7.- Fernández-Trillo, F., Fernández-Megía, E. and Riguera, R. Evaluation of amino acids as chiral ligands for the enantiodifferentiation of carbohydrates by TOCSY NMR. J. Org. Chem. 75, 3878–3881 (2010).


6.- Fernández-Trillo, F., van Hest, J. C. M., Thies, J. C., Michon, T., Weberskirch, R., and Cameron, N. R. Reversible Immobilization onto PEG-based Emulsion-templated Porous Polymers by Co-assembly of Stimuli Responsive Polymers. Adv. Mater. 21, 55–59 (2009).

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5.- Fernández-Trillo, F., van Hest, J. C. M., Thies, J. C., Michon, T., Weberskirch, R., and Cameron, N. R. Fine-tuning the transition temperature of a stimuli-responsive polymer by a simple blending procedure. Chem. Commun. 2230–2232 (2008).


4.- Fernández-Trillo, F., Dureault, A., Bayley, J. P. M., van Hest, J. C. M., Thies, J. C., Michon, T., Weberskirch, R., and Cameron, N. R., Elastin-based side-chain polymers: Improved synthesis via RAFT and stimulus responsive behavior. Macromolecules 40, 6094–6099 (2007).


3.- López, S., Fernández-Trillo, F., Midón, P., Castedo, L. and Saá, C. Synthesis of marine polyacetylenes callyberynes A-C by transition-metal-catalyzed cross-coupling reactions to sp centers. J. Org. Chem. 71, 2802–2810 (2006).


2.- López, S., Fernández-Trillo, F., Midón, P., Castedo, L. and Saá, C. First stereoselective syntheses of (-)-siphonodiol and (-)-tetrahydrosiphonodiol, bioactive polyacetylenes from marine sponges. J. Org. Chem. 70, 6346–6352 (2005).


1.- López, S., Fernández-Trillo, F., Castedo, L. and Saá, C. Synthesis of callyberynes A and B, polyacetylenic hydrocarbons from marine sponges. Org. Lett. 5, 3725–3728 (2003).


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7.- Leigh, T. & Fernandez-Trillo, P. Helical polymers for biological and medical applicationsNat Rev Chem 1–20 (2020) doi:10.1038/s41570-020-0180-5

6.- Fernandez-Trillo, F., Grover, L. M., Stephenson-Brown, A., Harrison, P., and Mendes, P. M. (2017) Vesicles in Nature and the Laboratory: Elucidation of Their Biological Properties and Synthesis of Increasingly Complex Synthetic Vesicles. Angew. Chem., Int. Ed. 56, 3142–3160.

5.- Insua, I., Wilkinson, A., and Fernandez-Trillo, F. Polyion complex (PIC) particles: Preparation and biomedical applications. Eur. Polym. J. 81, 198–215 (2016) – (UoB repository) – (PubMed Central)

4.- Monzó, J., Insua, I., Fernandez-Trillo, F., and Rodriguez, P. Fundamentals, achievements and challenges in the electrochemical sensing of pathogens. Analyst, 140, 7116–7128 (2015). – (UoB repository)

3.- Lallana, E., Fernández-Trillo, F., Sousa-Herves, A., Riguera, R. and Fernández-Megía, E. Click Chemistry with Polymers, Dendrimers, and Hydrogels for Drug Delivery. Pharm. Res. 29, 902–921 (2012).

2.- Lallana, E., Sousa-Herves, A., Fernández-Trillo, F., Riguera, R. and Fernández-Megía, E. Click Chemistry for Drug Delivery Nanosystems. Pharm. Res. 29, 1–34 (2011).

1.- Magnusson, J. P., Saeed, A. O., Fernández-Trillo, F. and Alexander, C. Synthetic polymers for biopharmaceutical delivery. Polym. Chem. 2, 48–59 (2010).

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Book Chapters

1.- Alexander, C. and Fernandez-Trillo, F. Bioresponsive polyplexes and micelleplexes, in Smart Materials for Drug Delivery. Alvarez-Lorenzo, C. and Concheiro, A. Eds, RSC Publishing (2013).

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